Study of the effects of ketamine and fentanyl on mid-latency auditory evoked potentials

The effects of ketamine and fentanyl on the mid-latency auditory evoked potentials were studied in 28 patients undergoing minor gynecological and surgical procedures. Latencies of the peaks V, Na, Pa, Nb, P1 and amplitudes of Na/Pa, Pa/Nb and Nb/P1 were measured in the awake state and 3 minutes, 6 minutes and 10 minutes after induction of ketamine for 14 patents [group 1] and after induction of fentanyl for 14 patients [group 2]. There was no significant change in peak latencies and amplitudes during anaesthesia with ketamine and with fentanyl compared to that of the awake state. Also, there was no significant change in peak latencies and amplitudes between group 1 [anaesthetised by ketamine] and group 2 [anaesthetised by fentanyl]. Therefore, the primary processing of auditory stimuli in the primary auditory cortex seemed to be preserved during general anaesthesia with ketamine or with fentanyl

Immunologic study on patients with chronic granular pharyngitis

A study of the SIgA levels in saliva, serum and pharyngeal mucosa with lymphoid tissue of 35 patients suffering from chronic granular pharyngitis was done by an immuno-chemical method. The results were compared with those from 30 healthy subjects served as a control group. The SIgA level in the saliva of the chronic granular pharyngitis patients was significantly lower than that of the control group. This may decrease the local immunity of the pharyngeal mucosa leading to repeated pharyngeal infections. The SIgA level was significantly higher in the pharyngeal mucosa with lymphoid tissue of the chronic granular pharyngitis patients than that of the control group. This may be due to repeated stimulation by microorganisms leading to rise of SIgA level strengthen the protective ability of the pharyngeal mucosa. No significant change was found in the SIgA serum levels of the chronic granular pharyngitis patients compared to the control group. These findings prove that SIgA has a local immune function that can be stimulated independently of systemic immunity. Our results stress the importance of raising and adjusting the immune function of the chronic granular pharyngitis patients beside other measures